Saidpur is a Mughal-era village on the slopes of the Margalla Hills and located off the Hill Road to the east of Daman-e-Koh in Islamabad. The village has the footprints of various civilizations, including Gandhara, Greek, Buddhist, Mughal, Ashoka and the colonial periods, and now serving as a popular recreational spot for both local and foreign visitors.ADLD arranged a prevalence project at this village to estimate the burden of disease especially of diabetes and liver diseases. It was headed by Dr Saleem Qureshi, Head of Department of medicine at KRL Hospital and CEO of ADLD (Alliance for diabetes and liver diseases).

World Diabetes Day 14th November 2010 event photos. It was headed by Dr Saleem Qureshi, Head of Department of medicine at KRL Hospital and CEO of ADLD (Alliance for diabetes and liver diseases). It was a healthy activity including activities to motivate young people who are at risk of developing diabetes to change their lifestyle and cultivate the habit of active lifestyle. It was arranged at The Pakistan Monument in Islamabad, Pakistan,which is a national monument representing the nation's four provinces and three territories. After a competition among many renowned architects, Arif Masood’s plan was selected for the final design. The event also included blue circle ceremony and lighting the candles marking the importance of that day.

Sorafenib is a multikinase inhibitor approved for cancer treatment that blocks the receptor tyrosine kinases VEGFR (Vascular Endothelial Growth Factor Receptor) and PDGFR (Platelet Derived Growth Factor Receptor) and the RAF serine/threonine kinases along the RAF/MEK/ERK pathway.

Sorafenib treatment induces autophagy, which may suppress tumor growth. However, autophagy can also cause drug resistance.

Mitogen-Activated Protein Kinase (MAPK*) Signalling Plays a Key Role in Governing Cell Proliferation, Differentiation, and Survival2MAPK signalling is transmitted along the RAS/RAF/MEK/ERK pathway† as follows:

• Activation of the small G protein RAS recruits of RAF1 to the inner surface of the cell membrane3
• RAF1 phosphorylates MEK3
• MEK phosphorylates and activates ERK downstream3
• Activated ERK translocates to the cell nucleus and regulates gene expression by interacting with various transcription factors4

ERK expression can be associated with more aggressive HCC
ERK expression in HCC is associated with5

• Increased tumour size
• Histologic progression
• Intrahepatic metastasis

Diabetes Ki Basti - Free Medical Camp -  is a project of CDLD (center for diabetes and Liver diseases) , a component of ADLD (Alliance for diabetes and liver diseases) to promote prevention, care and cure for people suffering from diabetes and liver diseases.

Imran Abbas is a Famous Pakistani actor and model. He is known for his leading roles in various famous television serials and Bollywood movies. He supports ADLD (Alliance For Diabetes And Liver Disease) and its component CDLD (Center For Diabetes And Liver Disease) in fighting diabetes and spreading awareness among people who are at risk. Become a member of ADLD to support our cause.