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Mechanism Of Action Of Sorafenib - CME Article By Dr. Usman Javed

12/10/2015

1 Comment

 

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Sorafenib is a multikinase inhibitor approved for cancer treatment that blocks the receptor tyrosine kinases VEGFR (Vascular Endothelial Growth Factor Receptor) and PDGFR (Platelet Derived Growth Factor Receptor) and the RAF serine/threonine kinases along the RAF/MEK/ERK pathway.

Sorafenib treatment induces autophagy, which may suppress tumor growth. However, autophagy can also cause drug resistance.

Mitogen-Activated Protein Kinase (MAPK*) Signalling Plays a Key Role in Governing Cell Proliferation, Differentiation, and Survival2MAPK signalling is transmitted along the RAS/RAF/MEK/ERK pathway† as follows:
  • Activation of the small G protein RAS recruits of RAF1 to the inner surface of the cell membrane3
  • RAF1 phosphorylates MEK3
  • MEK phosphorylates and activates ERK downstream3
  • Activated ERK translocates to the cell nucleus and regulates gene expression by interacting with various transcription factors4
ERK expression can be associated with more aggressive HCC
ERK expression in HCC is associated with5
  • Increased tumour size
  • Histologic progression
  • Intrahepatic metastasis
1 Comment
Sorafenib 200 mg Tablets link
10/14/2016 01:59:49 pm

Awesome post!!! I have no more word to say about this post, but would like suggest to the all people to go through on this at least one time

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